Dexmedetomidine dosing

Sedatives · 100 mcg/mL · IV Infusion

Calculated, not generated

Weight-based dose

Dose	Per kg	For 70 kg
low	0.2 mcg/kg/hr/kg	14 mcg/kg/hr
standard	0.5 mcg/kg/hr/kg	35 mcg/kg/hr
high	0.7 mcg/kg/hr/kg	49 mcg/kg/hr

Loading dose: 1 mcg/kg over 10 min (optional). Causes bradycardia & hypotension. No respiratory depression.

Renal & hepatic adjustment

Severe (Child-Pugh C)Hepatic metabolism — clearance is reduced; lower the dose/infusion and titrate to effect.

Source: Dexmedetomidine prescribing information

Evidence A · PRODEX/MIDEX trials; MENDS2 sedation study

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Vigil computes Dexmedetomidine for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.

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