4-Factor PCC (Kcentra) dosing
Miscellaneous · 500 unit vial (reconstitute) · IV Infusion
Calculated, not generatedWeight-based dose
| Dose | Per kg | For 70 kg |
|---|---|---|
| low | 25 units/kg | 1750 units |
| standard | 35 units/kg | 2450 units |
| high | 50 units/kg | 3500 units |
Warfarin reversal: INR 2-4: 25 units/kg; INR 4-6: 35 units/kg; INR >6: 50 units/kg. Max 100 mL (2500 units for 70 kg). Infuse at 0.12 mL/kg/min. Thrombosis risk.
Renal & hepatic adjustment
No drug-specific organ adjustment in our database — use clinical judgment and verify against the label.
Evidence A · FDA approved for warfarin reversal; superior to FFP
More miscellaneous
Get the exact dose for your patient
Vigil computes 4-Factor PCC (Kcentra) for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.
Decision support for licensed clinicians — not a substitute for clinical judgment. Always verify against the package insert and the patient in front of you.