Andexanet Alfa (Andexxa) dosing
Reversal · 100 mg vial (reconstitute) · IV Infusion
Calculated, not generatedWeight-based dose
| Dose | Per kg | For 70 kg |
|---|---|---|
| low | 5.5 mg/kg | 385 mg |
| standard | 11 mg/kg | 770 mg |
| high | 11 mg/kg | 770 mg |
Factor Xa inhibitor reversal (rivaroxaban, apixaban). Low dose: 400 mg bolus + 480 mg infusion (last dose >8 hr ago). High dose: 800 mg + 960 mg (last dose <8 hr or unknown).
Renal & hepatic adjustment
No drug-specific organ adjustment in our database — use clinical judgment and verify against the label.
Evidence A · ANNEXA-4 trial
More reversal
Get the exact dose for your patient
Vigil computes Andexanet Alfa (Andexxa) for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.
Decision support for licensed clinicians — not a substitute for clinical judgment. Always verify against the package insert and the patient in front of you.