Physostigmine dosing
Reversal · 1 mg/mL · IV Slow Push
Calculated, not generatedWeight-based dose
| Dose | Per kg | For 70 kg |
|---|---|---|
| low | 0.01 mg/kg | 0.7 mg |
| standard | 0.02 mg/kg | 1.4 mg |
| high | 0.03 mg/kg | 2.1 mg |
Typical: 1-2 mg IV slowly over 5 min. Crosses BBB — reverses central anticholinergic syndrome. May cause bradycardia, bronchospasm. Have atropine available.
Renal & hepatic adjustment
No drug-specific organ adjustment in our database — use clinical judgment and verify against the label.
Evidence B · Anticholinergic toxicity treatment literature
More reversal
Get the exact dose for your patient
Vigil computes Physostigmine for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.
Decision support for licensed clinicians — not a substitute for clinical judgment. Always verify against the package insert and the patient in front of you.