Mepivacaine dosing

Local Anesthetics · 1-1.5% (10-15 mg/mL) · Infiltration / Nerve Block

Calculated, not generated

Weight-based dose

Dose	Per kg	For 70 kg
low	3 mg/kg	210 mg
standard	4.5 mg/kg	315 mg
high	7 mg/kg	490 mg

Max without epi: 4.5 mg/kg. Max with epi: 7 mg/kg.

Renal & hepatic adjustment

Severe (Child-Pugh C)Amide local — reduced hepatic clearance; lower the maximum dose (LAST risk).

Source: ASRA LAST guidance

Onset, duration & pearls

Onset2-5 min

Duration90-180 min

Side effects: CNS toxicity, Allergic reactions (rare).

Intermediate duration amide LA
Avoid in obstetric epidurals — fetal ion trapping risk

More local anesthetics

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Vigil computes Mepivacaine for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.

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