Hydromorphone dosing
Opioids · 1 mg/mL · IV Push
Calculated, not generatedWeight-based dose
| Dose | Per kg | For 70 kg |
|---|---|---|
| low | 0.005 mg/kg | 0.35 mg |
| standard | 0.01 mg/kg | 0.7 mg |
| high | 0.02 mg/kg | 1.4 mg |
Renal & hepatic adjustment
- Severe (eGFR <30 / dialysis)Metabolite H3G can accumulate in renal failure (neuroexcitation) — reduce dose and monitor; still generally preferred over morphine.
- Severe (Child-Pugh C)Reduced clearance in severe hepatic impairment — reduce dose / extend interval.
Source: KDIGO; Stoelting’s Pharmacology
Onset, duration & pearls
Onset5-10 min
Duration3-4 hr
Side effects: Respiratory depression, PONV, Pruritus.
- 5-7x potency of morphine
- No active metabolites — preferred in renal impairment
More opioids
Get the exact dose for your patient
Vigil computes Hydromorphone for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.
Decision support for licensed clinicians — not a substitute for clinical judgment. Always verify against the package insert and the patient in front of you.