Morphine dosing

Opioids · 2 mg/mL · IV Push

Calculated, not generated

Weight-based dose

Dose	Per kg	For 70 kg
low	0.05 mg/kg	3.5 mg
standard	0.1 mg/kg	7 mg
high	0.15 mg/kg	10.5 mg

Renal & hepatic adjustment

Moderate (eGFR 30–59)Active metabolite M6G begins to accumulate — reduce dose / extend interval and monitor sedation.
Severe (eGFR <30 / dialysis)M6G accumulates substantially in severe renal impairment → prolonged sedation and respiratory depression. Reduce dose, extend interval, or use fentanyl/hydromorphone with caution.
Severe (Child-Pugh C)Reduced hepatic clearance — reduce dose and extend the dosing interval.

Source: KDIGO; Stoelting’s Pharmacology

Onset, duration & pearls

Onset5-10 min

Duration3-4 hr

Side effects: Histamine release, Hypotension, PONV, Pruritus.

Active metabolite M6G accumulates in renal failure
Histamine release can cause bronchospasm

More opioids

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