Methadone dosing
Opioids · 10 mg/mL · IV Push
Calculated, not generatedWeight-based dose
| Dose | Per kg | For 70 kg |
|---|---|---|
| low | 0.1 mg/kg | 7 mg |
| standard | 0.15 mg/kg | 10.5 mg |
| high | 0.2 mg/kg | 14 mg |
Long-acting (24-36 hr). NMDA antagonist. Useful for periop pain in spine/major surgery. Single intraoperative dose: 0.1-0.2 mg/kg. QTc prolongation risk.
Renal & hepatic adjustment
- Severe (Child-Pugh C)Complex hepatic metabolism and long half-life — reduce and titrate slowly; monitor QTc.
Source: Methadone prescribing information
Evidence B · Murphy meta-analysis; perioperative methadone RCTs
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Get the exact dose for your patient
Vigil computes Methadone for your patient's actual weight — and adjusts for renal or hepatic impairment automatically, with the cited rationale. The number is calculated from a verified database, never guessed.
Decision support for licensed clinicians — not a substitute for clinical judgment. Always verify against the package insert and the patient in front of you.